Lixisenatide reduces glycaemic variability in insulin-treated patients with type 2 diabetes.
Identifieur interne : 000885 ( Main/Exploration ); précédent : 000884; suivant : 000886Lixisenatide reduces glycaemic variability in insulin-treated patients with type 2 diabetes.
Auteurs : Guillermo E. Umpierrez [Géorgie (pays)] ; David O'Neal [Australie] ; Andres Digenio [États-Unis] ; Ronald Goldenberg [Canada] ; Eric Hernandez-Triana [Colombie] ; Jay Lin [États-Unis] ; Cheol-Young Park [Corée du Sud] ; Eric Renard [France] ; Boris Kovatchev [États-Unis]Source :
- Diabetes, obesity & metabolism [ 1463-1326 ] ; 2017.
Abstract
Chronic hyperglycaemia and glucose variability are associated with the development of chronic diabetes-related complications. We conducted a pooled analysis of patient-level data from three 24-week, randomized, phase III clinical trials to evaluate the impact of lixisenatide (LIXI) on glycaemic variability (GV) vs placebo as add-on to basal insulin. The main outcome GV measures were standard deviation (s.d.), mean amplitude of glycaemic excursions (MAGE), mean absolute glucose (MAG) level, area under the curve for fasting glucose (AUC-F), and high (HBGI) and low blood glucose index (LBGI). The change in GV metrics over 24 weeks and relationships among baseline GV, patient characteristics and outcomes were assessed. Data were pooled from 1198 patients (665 LIXI, 533 placebo). Values for s.d., MAG level, MAGE, HBGI, and AUC-F significantly decreased with LIXI vs placebo, while LBGI values were unchanged. Higher baseline GV measures correlated with older age, longer type 2 diabetes duration, lower body mass index, higher baseline glycated/haemogobin, greater reduction in postprandial glucose (PPG) level, and higher rates of symptomatic hypoglycaemia. These data show that LIXI added to basal insulin significantly reduced GV and PPG excursions vs placebo, without increasing the risk of hypoglycaemia (LBGI).
DOI: 10.1111/dom.12930
PubMed: 28256054
Affiliations:
- Australie, Canada, Colombie, Corée du Sud, France, Géorgie (pays), États-Unis
- Languedoc-Roussillon, Massachusetts, New Jersey, Occitanie (région administrative), Région capitale de Séoul, Victoria (État), Virginie
- Melbourne, Montpellier, Séoul
- Université de Melbourne
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sortKey="Umpierrez, Guillermo E" sort="Umpierrez, Guillermo E" uniqKey="Umpierrez G" first="Guillermo E" last="Umpierrez">Guillermo E. Umpierrez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Emory University of Medicine, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Department of Medicine, Emory University of Medicine, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="O Neal, David" sort="O Neal, David" uniqKey="O Neal D" first="David" last="O'Neal">David O'Neal</name><affiliation wicri:level="4"><nlm:affiliation>University of Melbourne, Department of Medicine, St Vincent's Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Melbourne, Department of Medicine, St Vincent's Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Digenio, Andres" sort="Digenio, Andres" uniqKey="Digenio A" first="Andres" last="Digenio">Andres Digenio</name><affiliation wicri:level="2"><nlm:affiliation>AKCEA Therapeutics, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>AKCEA Therapeutics, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Goldenberg, Ronald" sort="Goldenberg, Ronald" uniqKey="Goldenberg R" first="Ronald" last="Goldenberg">Ronald Goldenberg</name><affiliation wicri:level="1"><nlm:affiliation>LMC Diabetes and Endocrinology, Thornhill, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>LMC Diabetes and Endocrinology, Thornhill, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Triana, Eric" sort="Hernandez Triana, Eric" uniqKey="Hernandez Triana E" first="Eric" last="Hernandez-Triana">Eric Hernandez-Triana</name><affiliation wicri:level="1"><nlm:affiliation>Endocare Research Institute, Universidad del Rosario, Bogota, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Endocare Research Institute, Universidad del Rosario, Bogota</wicri:regionArea><wicri:noRegion>Bogota</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Jay" sort="Lin, Jay" uniqKey="Lin J" first="Jay" last="Lin">Jay Lin</name><affiliation wicri:level="2"><nlm:affiliation>Novosys Health, Green Brook, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novosys Health, Green Brook</wicri:cityArea></affiliation></author><author><name sortKey="Park, Cheol Young" sort="Park, Cheol Young" uniqKey="Park C" first="Cheol-Young" last="Park">Cheol-Young Park</name><affiliation wicri:level="3"><nlm:affiliation>Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Renard, Eric" sort="Renard, Eric" uniqKey="Renard E" first="Eric" last="Renard">Eric Renard</name><affiliation wicri:level="3"><nlm:affiliation>Department of Endocrinology, Diabetes, Nutrition, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Endocrinology, Diabetes, Nutrition, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Kovatchev, Boris" sort="Kovatchev, Boris" uniqKey="Kovatchev B" first="Boris" last="Kovatchev">Boris Kovatchev</name><affiliation wicri:level="2"><nlm:affiliation>Center for Diabetes Technology, University of Virginia Health System, Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Diabetes Technology, University of Virginia Health System, Charlottesville</wicri:cityArea></affiliation></author></analytic><series><title level="j">Diabetes, obesity & metabolism</title><idno type="eISSN">1463-1326</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic hyperglycaemia and glucose variability are associated with the development of chronic diabetes-related complications. We conducted a pooled analysis of patient-level data from three 24-week, randomized, phase III clinical trials to evaluate the impact of lixisenatide (LIXI) on glycaemic variability (GV) vs placebo as add-on to basal insulin. The main outcome GV measures were standard deviation (s.d.), mean amplitude of glycaemic excursions (MAGE), mean absolute glucose (MAG) level, area under the curve for fasting glucose (AUC-F), and high (HBGI) and low blood glucose index (LBGI). The change in GV metrics over 24 weeks and relationships among baseline GV, patient characteristics and outcomes were assessed. Data were pooled from 1198 patients (665 LIXI, 533 placebo). Values for s.d., MAG level, MAGE, HBGI, and AUC-F significantly decreased with LIXI vs placebo, while LBGI values were unchanged. Higher baseline GV measures correlated with older age, longer type 2 diabetes duration, lower body mass index, higher baseline glycated/haemogobin, greater reduction in postprandial glucose (PPG) level, and higher rates of symptomatic hypoglycaemia. These data show that LIXI added to basal insulin significantly reduced GV and PPG excursions vs placebo, without increasing the risk of hypoglycaemia (LBGI).</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Colombie</li><li>Corée du Sud</li><li>France</li><li>Géorgie (pays)</li><li>États-Unis</li></country><region><li>Languedoc-Roussillon</li><li>Massachusetts</li><li>New Jersey</li><li>Occitanie (région administrative)</li><li>Région capitale de Séoul</li><li>Victoria (État)</li><li>Virginie</li></region><settlement><li>Melbourne</li><li>Montpellier</li><li>Séoul</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Umpierrez, Guillermo E" sort="Umpierrez, Guillermo E" uniqKey="Umpierrez G" first="Guillermo E" last="Umpierrez">Guillermo E. Umpierrez</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="O Neal, David" sort="O Neal, David" uniqKey="O Neal D" first="David" last="O'Neal">David O'Neal</name></region></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Digenio, Andres" sort="Digenio, Andres" uniqKey="Digenio A" first="Andres" last="Digenio">Andres Digenio</name></region><name sortKey="Kovatchev, Boris" sort="Kovatchev, Boris" uniqKey="Kovatchev B" first="Boris" last="Kovatchev">Boris Kovatchev</name><name sortKey="Lin, Jay" sort="Lin, Jay" uniqKey="Lin J" first="Jay" last="Lin">Jay Lin</name></country><country name="Canada"><noRegion><name sortKey="Goldenberg, Ronald" sort="Goldenberg, Ronald" uniqKey="Goldenberg R" first="Ronald" last="Goldenberg">Ronald Goldenberg</name></noRegion></country><country name="Colombie"><noRegion><name sortKey="Hernandez Triana, Eric" sort="Hernandez Triana, Eric" uniqKey="Hernandez Triana E" first="Eric" last="Hernandez-Triana">Eric Hernandez-Triana</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Park, Cheol Young" sort="Park, Cheol Young" uniqKey="Park C" first="Cheol-Young" last="Park">Cheol-Young Park</name></region></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Renard, Eric" sort="Renard, Eric" uniqKey="Renard E" first="Eric" last="Renard">Eric Renard</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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